Targeting Nipah virus. The zoonotic Nipah virus (NiV) was discovered in 1999, and since then outbreaks in humans have been recorded almost annually in parts of Asia. This virus causes encephalitis and respiratory symptoms that can be serious and often fatal. Viral entry into host cells requires the attachment glycoprotein (G) and the fusion glycoprotein (F), and these proteins are targeted by the immune system. Z. Wang et al. determined the structure of the tetrameric ectodomain of the NiV G protein in complex with a broadly neutralizing antibody. Vaccinating macaques with the ectodomain tetramer elicited antibodies against the G protein head domain, resulting in potent neutralizing activity against NiV. The structure provides a blueprint for engineering next-generation vaccine candidates . —VVScience, abm5561, this issue p. 1373Three broadly neutralizing antibodies (purple) bound to the Nipah virus ectodomain tetramer
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